Monday, August 24, 2020
Moby Dick Essays (699 words) - Moby-Dick, Captain Ahab, Ishmael
Moby Dick MEN GONE MAD People groups dreams can make them crazy. One individual can be totally centered around a specific occasion that the occasion before long starts to assume control over their life and impact others. Skipper Ahabs aim is finding and murdering Moby Dick, the whale that harmed and deformed him years prior. His fixation on this whale places numerous others at serious risk, for example, Ishmael, Starbuck, and himself. Commander Ahab utilizes his shipmates as trap for Moby Dick himself. The day the boat departs the harbor on a quest for whales, the men are caught in a world gone frantic with no way out. Ishmael, Starbuck, and Captain Ahab are completely caught in a disastrous disaster. Prior to boarding the boat, Ishmael sees an individual on the harbor alongside the whaling vessel. This people name is Elijah, fortuitously having a similar name as the prophet. Elijah indications to Ishmael to turn around from this journey while he despite everything has time. Elijah expresses that Ahab will smell land where there be none, Ahab will go to his grave yet will ascend inside one hour and call, and all spare one will be wrecked. Ishmael ignores him and proceeds. At the point when Ishmael is prepared to board the boat, Elijah cautions him once more. This is an indication that something horrendous will happen once on board the boat and everything and everybody will be damaged. In the event that solitary Ishmael would know, he will before long be caught in Ahabs insane world. Playing out an agnostic ceremony before the sleepy team, Captain Ahab swears the men to go along with him in chasing down the white whale Moby Dick and murdering him to fulfill Ahabs want for retribution. Starbuck is shocked, while the insane yelling of their commander uncontrollably moves individuals from the boat. This is an insidious journey. I dread the fierceness of God. Administration to humanity that satisfies God isn't revenge.1 Greatly dreading what Ahab has in store on the planet gone frantic, Starbuck predicts catastrophe. Nailing a doubloon to the primary pole follows the insane blustering and Ahab says, Whosoever of ye raises me a white-headed whale with a wrinkled forehead and an abnormal jaw, he will have this gold ounce, my boys!2 Starbuck discloses to Ahab that he came to chase whales, not his administrators retaliation. As the savage harpooners drink, Death to Moby Dick! Starbuck mumbles, God help me!keep us all!3 Starbuck is very much aware that Ahab will before lo ng spot all the men in impending peril. Investing the greater part of his energy in deck and just only from time to time slipping into the lodge, Ahab has all the earmarks of being a thoughtful character in certain angles. During the night watches, old Ahab is at hand, pacing with his fake leg. Ahab has been in look for Moby Dick previously however Moby Dick got away from the crazy chief. Ahab has been caught in a world gone frantic for an amazingly prolonged stretch of time. Since the day he couldn't get the dreaded Moby Dick, his life was never the equivalent. Ahab himself is caught in franticness and states, May God damn all of us in the event that we don't chase Moby Dick to his death!4 Starbuck sees Captain Ahabs whale map and opposes this idea. Ahab characterized he unmistakably comprehended what he was doing, Dumb beast blasphemykills and ravage out race. I would strike the sun on the off chance that it outraged me,5 and he would not let Moby Dick escape this time regardless of what the situation. Ahab was very much aware of the caught world he was exacting on the shipmates yet was uniquely out for a certain something; his obsessive self. Subsequently, the blameless men are caught in a world gone frantic the very day the boat departs the harbor. Ishmael, Starbuck, and Captain Ahab are totally caught in a universe of disaster. These men were caught by the franticness of Captain Ahab. It was surely their freewill to board the boat, yet when they boarded they were accidental of Ahabs lunacy and disdain for Moby Dick. People groups dreams can to be sure make them ballistic and Ahab was one of those individuals. English Essays
Saturday, August 22, 2020
Psychologists and Jury Selection Term Paper Example | Topics and Well Written Essays - 750 words
Analysts and Jury Selection - Term Paper Example The scientist expresses that in the event that, for example, Bruno Hauptmann, there could be solid open state of mind against the blamed which could impact the jury to convict the guiltless. Here, the juristsââ¬â¢ character attributes and characteristics may assume a significant job. In a media power society, it is especially evident as it frequently compensation mental wars to assemble popular conclusion over what it considers as truth. The preliminary of O. J. Simpson was portrayed by ââ¬Ëcontinued media intrigue and open interest with his activities and proclamations. The conviction that ââ¬Å"he pulled off murderâ⬠even prompted recommendations to change and limit the jury systemââ¬â¢. The assurance important to rebuff nay charged could be gathered by the law specialists dependent on their preferences and perspective. Above all, as indicated by Greene et.al, ââ¬Ëtruth is subtle, and in the lawful framework, all fact searchers are dependent upon human blunder, de spite the fact that the framework appears to expect that they approach trustworthiness. The inability to accomplish flawlessness in our dynamic will get clear as the means in the preliminary procedure are reviewedââ¬â¢. Jury notions are straightforwardly a result of juristsââ¬â¢ feelings, mentalities and convictions. Lawyers have two alternatives for choosing new juries. Most importantly, a board of forthcoming members of the jury should be distinguished which is known as venire. Besides, ââ¬Ëa process known as voir desperate is utilized to address and select the possible jurorsââ¬â¢. It includes each law specialist educating truth concerning himself/herself. This procedure normally includes disposal as the legal advisers who hold predispositions over a specific case are excused from the preliminary. Just the ones who hold a free psyche and liberated from impediments are chosen. There is a distinction between judgesââ¬â¢ choices and Juriesââ¬â¢ choices. It has been discovered that ââ¬Å"citizens accept a jury choice offers increasingly procedural reasonableness (more prominent carefulness, better portrayal of the network, less close to home predispositions influencing choices) than a choice by a judgeâ⬠. Jury opinions are the significant reason for the inconsistencies in the legal decisions. In their acclaimed overview, ââ¬ËKalven and Zeisel, in the wake of inspecting the huge number of inconsistencies, utilized this term to cover all preliminaries where, in the judgeââ¬â¢s see, the juryââ¬â¢s decision was unfavorably dictated by factors past the proof and the lawââ¬â¢. Particularly in harmless wrongdoings, there could a more grounded propensity for conclusions towards the guilty party. At times, if the case gets increasingly social significance through media intercession, the quantity of legal scholars might be generally high. It is troublesome even to keep the jury determination system similarly as it would include oppress ion minority religions, races, nationalities and other cognizable gatherings.
Wednesday, July 22, 2020
High School Entrance Essay Samples
High School Entrance Essay SamplesHigh school entrance essays are the first step to a bright future of education. They are the beginning of your life as a student and can help you be a great student who knows how to write well.Essays are becoming more important, especially now that everyone is moving to college. Being able to get a scholarship and attending a prestigious college can only be accomplished by a great performance in the high school entrance exam. The essays are the first step to making this dream come true.Although the best essay writing skills are developed with practice, there are essay writing samples that can help you improve your chances. These essays will be helpful if you are having trouble coming up with something for your essay to relate to.Although most people do not think they need to be perfect when they write an essay, there are some students who have great writing skills but do not have the perfect entry or conclusion for their essay. This can be frustratin g. With the help of these essays, you can come up with a great ending and save yourself some time and trouble.You can get the perfect written document that you have always wanted by looking at some professional essay samples. You can find some great examples online and take a look at them before you go to write your own essay. There are many ways to improve your own essay, so it is very important to get a few practice samples.Good high school entrance essay samples can help you learn a lot of information about what to write about. For example, you may want to make sure that you cover all the bases when you are doing your research for your essay. By reading other people's essays, you will find that you can answer more questions than you could have guessed.You can also use the essays you read online as great practice when you are writing your high school entrance essay. You will find that there are a lot of essay examples that you can look at to get a feel for what it takes to make a great essay. The high school entrance essay samples will show you where to begin and also give you some tips on how to improve your essay as you go along.High school entrance essay samples can be used as a guide and can give you some tips on how to write a good essay. You will find that a lot of the essays are written by someone who has already been through the process and has become the best essay writer ever. It can help you a lot to gain some ideas and if you can follow those ideas you will end up with a well-written high school entrance essay.
Friday, May 22, 2020
What Judges Look for in a Science Fair Project
How do you know what makes a great science fair project? Here are some pointers for making sure you have a good project, based on what science fair judges are looking for in your project. Be Original: Science fair judges are looking for inventions and innovations. Try to come up with an original idea for your science fair project. Find a new way to test something or a fresh application for a product or a novel way to process data. Look at something old in a new way. For example, rather than compare different types of coffee filters, you could compare different household materials (paper towels, napkins, toilet paper) for use as coffee filters if you ever ran out.Be Clear: Have a well-defined, easy-to-understand goal or objective. Make sure the title of your project is related to your purpose. Make it crystal clear what you are doing and why.Understand Your Science Fair Project: Its not enough to have an easy-to-understand poster or presentation. Judges will ask you questions about your project, in part to see whether or not you understand what you have done. This weeds out people who basically had their parents, friends, or teacher do their project for them. You need to understand what you did, why you did it, and what conclusions you could make based on your results.Be Professional: Have a neat, professional-looking poster and dress nicely for the science fair. While you should do your project yourself, its fine to enlist help from a parent or teacher in putting together a poster and an outfit. You are not being graded on your appearance, but taking pride in your appearance will help you radiate confidence. Neatness counts with your project since good organization will beà making it easier for the science fair judge to follow what you have done.Time Effort: Science fair judges reward effort. You can get excellent marks on a science fair project that only took you an hour to do, but you should realize investing time and energy in your project will give you an edge over other good projects. A project does not need to be time-consuming or complicated, but one which requires you to collect data over time will do better than a project you whipped out in a weekend. Spending time on your project demonstrates your interest in it, plus taking the time to think about it usually means you come out of the project with a better understanding of how science works.Answer Questions: You can impress science fair judges by answering their questions politely and completely. Try to radiate confidence. If you dont know the answer to a question, admit it and try to offer a way you could come up with the answer. Here are some common questions asked by science fair judges:How did you come up with the idea for this science fair project?How long did you spend on the project?What background research did you conduct? What did you learn from it?Did anyone help you with the project?Does this project have any practical applications?Did you try anything that did not work or did not give you expected results? If so, what did you learn from this?What would be the next step in this experiment or study if you wanted to continue your work?
Thursday, May 7, 2020
My Influence Of Sports On My Life - 2086 Words
Through my life, I have always been willing to try new things. I have learned it is ok to fail, no matter how many times, as long as I keep trying. Out of the many interests that I have pursued, one thing stands out to me. I love sports. I have participated in sports since a young age, and I have discovered that a vast majority of my relationships have been made through the sports world. I can talk about sports all day long. My obsession started at a young age. The first memory I have of watching sports was on February 1st, 2004. That was the date of Super Bowl 38. Before that date, I did not really know much about football. After that game, I desired to know as much as possible. On that day, I remember running around my house like anyâ⬠¦show more contentâ⬠¦That Super Bowl win in 2004 subconsciously initiated my quest to become an NFL general manager. When I turned seven years old, my parents bought me Madden 2006 for my birthday. That same year I begged my parents to sign me up for the local football league. Football was my first love. If I wasnââ¬â¢t at the field practicing football, I was throwing with my dad and other kids in the neighborhood. Sometimes I would beg other kidsââ¬â¢ dads to throw to me because their kids couldnââ¬â¢t throw it hard enough or far enough. When I was tired and couldnââ¬â¢t play any more football, I would come home and play Madden. I played Madden religiously. I played with every NFL team and learned as many names as I could. The thing that captivated me about Madden was the player ratings. Each player had numeric attributes numbered from 25 to 99 that affected their overall rating. The ratings included speed, strength, acceleration, agility, catching, tackling, and awareness. My favorite thing to do was to look through the numbers. I slowly memorized the names of hundreds of NFL players and used the attributes to determine what type of player they were. I used a composition notebook to write down names of my f avorite players. I wrote down some of their notable attributes in the journal. On Sundays, I would watch NFL games all day and watch the players I wrote in my journal. I wondered what it would be like to put together a team with all theShow MoreRelatedWhat Creates Happiness And Good Health1223 Words à |à 5 Pages In life there are ways we come to a deeper meaning of what creates happiness and good health. To achieve the deeper meaning we exhaust the ideas of playing sports, creating art, or making things to better the lives of people around us. We all understand art is a part of our daily life, and how we choose to use or create the art affects our personal self. Throughout the semester there are aspects of the teaching which have changed the way I notice and create my art in my life. I focus heavily onRead MoreI Am On The Uconn Women s Basketball Team1165 Words à |à 5 Pagesdoing in Connecticut?â⬠My response is always the same, ââ¬Å"Iââ¬â¢m on the UConn womenââ¬â¢s basketball team.â⬠Sport has played a large role in my life and has definitely impacted me. My parents were key factors that helped me get to where I am now. Both of my parents were college athletes. My father played basketball at Marquette University in Milwaukee, Wisconsin. Before that, he was an all- state basketball player, tennis player and pitched for his high school baseball team. My mother played tennis atRead MoreGender Roles Since High School Essay1334 Words à |à 6 PagesGender roles resurfaced as a pivotal factor in my life during my late adolescence. In our culture different sports are considered to be male and female dominated respectively. Unfortunately little is done to challenge or resist these societal norms and I experienced this first hand during my senior year of high school. 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What I have experienced from beingRead MoreStudent: Exercise and Badminton Club Essay1048 Words à |à 5 Pages Badminton and Figueroaââ¬â¢s Framework Introduction The purpose of this research is to connect Figueroaââ¬â¢s Framework to my decision to join or not a badminton club. After close examination I choose the 2 levels that for me have the most significant impact on peopleââ¬â¢s decision on sports and describe them linking with badminton. Badminton Badminton is a racquet sport played by either two opposing players (singles) or two opposing pairs (doubles), who take positions on opposite halves of a rectangularRead MoreSports As A Young Age843 Words à |à 4 PagesAt a young age, my parents put me in sports: teaching me how to skate at age three, playing football my first year eligible and playing t-ball a year early. Sports can teach a child more than just how to throw a football or shoot a puck, sports have the power to teach a child how to become an adult. Children who are involved in sports at a young age are taught many necessary traits in life. Sports can impact their life and teach them competition, respect and responsibility. Three very valuable traitsRead MoreEthic Essay1469 Words à |à 6 Pagescontact with, influences inside the home such as parents, siblings, and neighbors. As one grows older and ventures out into the world outside the home teachers, friends and even enemies all help to shape oneââ¬â¢s value sy stem. Any type of communication with anyone that we come in contact with has the potential to shape our value system or our ethics structure. Good. Ethics Development Oneââ¬â¢s beliefs, values or ethics begin forming at an early age and continues throughout oneââ¬â¢s life. Most oftenRead MoreHow Sports Can Help Someone Out Socially843 Words à |à 4 Pages1) Sports have played an important role in my life ever since I was very young. Because of sports, I am very confident in myself. Although many people believe sports are just to have fun and stay active, I believe that their influence leaves more behind. I believe that playing sports can help someone out socially, physically, and mentally. Participating in sports has completely and utterly transformed me into the person that I am today. 2) I believe playing sports can help many people throughout
Wednesday, May 6, 2020
Wal-Mart Performance Free Essays
Globalization has had a positive impact on planning in Wal-mart organization. This is because Wal-mart stakeholders are able to estimate the profit it can make by allowing its cheaply manufactured and inexpensive goods and services to cross the borders and reach other countries of the world. (James, 1999) defines industry attractiveness as the prevailing situation in the core business of an organization which favors the specific organization for example in monotheistic business environment, a business is more likely to be favor in terms of business performance since it can manipulate market forces to its advantage. We will write a custom essay sample on Wal-Mart Performance or any similar topic only for you Order Now Even in a market environment, less than 4 competitors are likely to influence the market situation to their advantage hence creating an attractive market environment. Wal-Martââ¬â¢s performance has been termed as sterling by many business analysts. The chain has recorded a profit after taxes of above $200 billion. By applying concepts like vendor managed inventories as well as just-in-time concept, Wal-Mart has continued to maintain leadership in the retail market in the US. Wal-Mart endeavors to remain a low-cost retailer, and by that it has been very effective in maintaining market attractiveness. By all means Wal-Mart has achieved low cost retail prices mostly because it manages to source goods at the best possible market prices. This is possible through the strategy of replenishing stock daily in which it allows its key suppliers to access data on sales, which in turn ensures that stocks are supplied just in time. Wal-Mart has successfully cut expenses in that it is able to save costs which would otherwise have gone to hiring warehouses, paying for the storage and security of the goods in warehouses, the costs which goes with insurance as well as the risk of destruction resulting from fire, and other natural calamities as well as expiry of perishable goods. By paying the suppliers based on what is sold the company ensures a zero cost in inventories, this in turns affords the company an opportunity to lower prices since there are less expenditures. In long term, this contributes to industry attractiveness. The other area in which the company has achieved competitive advantage is in terms of adapting information systems. By doing that, Wal-Mart, has become a low cost producer in that it achieves effectiveness and therefore minimizing losses. The organization has set out to be a market leader. In terms of incorporating information technology, Wal-Mart has computerized its purchasing systems to incorporate E-purchasing. As a purchasing strategy, e-purchasing is economically reliable and cost effective. Compared to a competitor who does have not adopted the e-purchasing concept, Wal-mart has been able to save a lot of money and time. According to (Kendel, 2004), competitive advantage also depends on how companies utilize and take advantage of the buyer power. To this end, Wal-Mart has outshone all its competitors in that, it is refuted to be one of the organizations in the US, which has been able to get suppliers to act according to its terms. In fact some have argued that, it manipulates and coerces suppliers to enter into concessions, which end up benefiting the retailer but harming the suppliers. In terms of the threat of substitutes, it is widely believed that, Wal-Mart no longer competes with any one, it has taken virtual control and is a major player of the US economy leave alone the retail business. In terms of supplier power, the suppliers are no longer able to contain the pressure from Wal-Mart; there have been reports of CEOââ¬â¢s agreeing to terms, which end up harming their businesses. Wal-Mart as earlier mentioned often coerces its suppliers into deals, this is not the case with its competitors which do not necessarily have the power to match it. Finally Wal-Mart unlike so many of its rivals have been able to penetrate with ease and so far commands a good share of the retail business in the US. However, it is Wal-Martââ¬â¢s expansive sales returns that continue to put it ahead of competitors in that, they can powerfully bargain with suppliers for best offers, which on their part the competitors cannot match. By integrating IT through out the whole retail chain Wal-mart ensures that, its partners are free and feel respected and therefore trade is done in an environment of cordial relationships. With a retail network of over 140 branches all over the world, the management styles as well Wal-Martââ¬â¢s purchasing, distribution and warehousing, in-store operations, marketing, Information Technology, Human Resource Management, and organization and management systems/style have to be maintained at a high notch. Otherwise, it would be impossible for the outlets to achieve unity of purpose. With such a huge work force, success can only be achieved only if there is proper human resource management. The organization has introduced performance based pay, which has gone down very well with the employees. A well motivated staff is the greatest asset for a company and therefore Wal-Mart has been able to achieve that through introducing modern employee management systems which aims at ensuring that, the best staff are retained and also that, staff get well compensated for their hard-work. This has given Wal-Mart a cutting edge advantage, in that, it is able to attract and keep the best workers. In terms of supplies, Wal-Mart has been able to cut lead time after streamlining its supply chain management. By doing that, Wal-Mart have come to be regarded as the industries leaders in terms of efficiency and cost cutting. Wal-Mart Stores, Inc is the worldââ¬â¢s largest retailer with over $200 billion worthy of annual sales. The organization has adopted various strategies to become and remain a market leader in the industry. Of all strategies, it is its low cost of products that has made the biggest contribution to its market attractiveness as well as its competitive advantage. Human resource management. According to available statistics, the company has over 1. 3 million employees also known as associates, it is spends a lot on employee development something which gives it a competitive edge as one of the most preferred employers. Wal-Mart has been ranked by the Fortune magazine as one of the most admired places in the world. This translates to attractiveness to both business partners and customers. Also as a strategy in supplies management the organization has avoided reliance on single suppliers but has instead engaged different suppliers. This helps in ensuring that, the suppliers do not dictate the terms since they are aware that they can be substituted. This is effective in that, it becomes very hard for suppliers to collaborate and decide the terms for the organization. Wal-Mart also ensures proper communication through the setting up of a satellite network, which interlinks all its branches to a central command. This has seen the company investing heavily in information technology, which in return has ensured that the company achieves economies of scale. Competitive advantage. Kmart is one of the key competitors which has found the going getting tough and has almost been left struggling to remain in business. The fact that, Wal-Mart controls over 70% of the retail business clearly shows that, the competition is not as stiff. Therefore, Wal-Mart is poised to remain a force even into the foreseeable future. The threats which it should deal with and undertake to solve include: negative publicity in that, the fact that it drives many other businesses out of business can lead to harmful price wars which could lead to the company loosing its current market share. Management Systems Several, problems and challenges such as shoplifting caused the company to invest in costly surveillance systems aimed at addressing the arising issues. Managers at Wal-Mart are motivated in that, the organization always rewards creativity and effort as well as originality. This has been a plus for the company as productivity is always related with highly motivated staff as well as employees who can identify well with the organization. Its people-friendly approach has led to such a good relationships with customers that, a very loyal client base has been achieved. By adopting new technology, production, administration and leadership in the company are one of the best in the world. The styles from other successful organizations of the world so that it can experience great success. Wal-Mart has now heavily invested in technology like computerized tracking systems, which enables them to track supply and monitor progress. Wal-Mart has experienced rapid growth partly due to a human resource policy, which handles. Globalization has enabled the organnization to expand the organization from rural small towns to urban areas. Also Wal-Mart enjoys a very loyal consumer base. Globalization has also enabled the leadership of Wal-Mart to expand the organization to so many areas externally, where they attract a lot of customers therefore making lots of profit. This has been achieved by lowering the prices of the goods, as a result of global nature of manufacturing. In terms of sustainability, Wal-Martââ¬â¢s strategy is market tested and it is very likely that, customers will always go for cheaper quality and therefore the strategy of low-cost will lead the organization from success to success. The fact that, Wal-Mart does not spend on inventories but uses a system where by delivery of goods is done by the suppliers saves the company a lot of money. This affects prices f commodities in that, so many suppliers want to engage the organization in business and therefore are willing to operate under terms that the organization dictates. Wal-Mart although has been favored by globalization needs to be wary of emerging issues such as the ones touching on ethics. Other threats for Wal-Mart include: Ethically, it has been accused of oppressing suppliers to an extent whereby, they are forced to lay-off employees hence causing joblessness as well as leading to closure of manufacturing plants on the US in favor of imports which are cheaper and therefore can be distributed to the retailer at much cheaper rates. Bargaining power is another crucial strength for the company, it virtually controls all the decisions or contracts entered with other companies that is, suppliers. Wal-Mart engages in a continuous improvement campaign in what consumers view as being on the move every time. To consumers and customers, this is viewed as an advantage since they know that every time the retailer makes a move, prices drop and therefore the company is seen as a better option by many. Efficiency is one factor that Wal-Mart has achieved by investing in modern systems. The company has been able to transact business worldwide with ease while at the same time minimizing cost. The fact that Wal-Mart has created a positive image for itself has ensured a constant demand for services and goods something which competitors have not been able to match. Wal-Mart has maintained a public image and therefore this helps. How to cite Wal-Mart Performance, Papers
Monday, April 27, 2020
Kfc International Business free essay sample
At first the Colonel started to implement the franchising business operation with the Chicken Secret Recipe by travel tower to tower. In 1960s because of the Colonelââ¬â¢s hard working Kentucky Fried Chicken had some 600 franchised outlets in US and Canada. The most important year was 1974. In 1974 the American giant, Heublein bought Kentucky Fried Chicken and the Colonel remained a public spokesman for the enterprise. Heublein was willing to support the Kentucky Fried Chickenââ¬â¢s aboard expansion plan and constantly implemented the franchising business operation. Kentucky Fried Chicken became more famous in the world.After that the enterprise was sold twice. Finally the Kentucky Fried Chicken was taken over by PepsiCo in 1986. In order to decrease the risk, PepsiCo remain the franchising business operation. Despite it decreased the financial risk, the local franchisees insisted to make the maximizing profits. Therefore the local franchisees did not care about quality, service and cleanness (QSC). We will write a custom essay sample on Kfc International Business or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page But the most important element that KFC got the success was Quality, Service and Cleanness (QSC). So the enterprise wanted to find out the balance between corporate and cultural sensitivity.Discussion and Analysis According to the case of Kentucky Fried Chicken and the Global Fast-Food Industry from Jeffrey A, this part of report will be divided into five main aspects to illustrate: International trade theories, FDI, Risk and Opportunities, Marketing, Strategies. International trade theories International trade theories help managers deal with the international businessââ¬â¢s problem and influence the decision of strategies. And this part will be divided in to three parts: culture, political, legal and economics. Culture Culture situation for international business is a big problem.In 1980s KFC started to build the restaurants in German. But KFC filed in the German market because Germans did not like take-out food. However McDonald could get the success in German. McDonald made many changes to adapt the German market. Firstly McDonald changed the menu which Germans liked. Such as, German beer was provided in the restaurants. But KFC was more success in Asia and Latin America because chicken was the traditional dish in there. Political In 1994, United States, Canada and Mexico created the North American Free Trade Agreement (NAFTA). There were not any tariffs on goods traded between those three countries. KFC had a good chance to development because of NAFTA. Economics Mexico was a big market in Latin American for KFC. It had 98 million people and the transportation casts was low resulted in Mexico was near US. Also the wages in Mexico was lower than the USââ¬â¢s. In US the higher divorce rate was seen by the government. More and more individuals often ate out and mostly married women chose to ate outside because they had careers. The demographic changes created a good economic environment to expand the fast-food chain.Legal In 1990 Mexico acted a new law. The new law protected the technology transferred. The taxes about technology assistance were increased to 35%. During that time KFC built rapidly many franchised restaurants.. FDI Franchising and Licensing Licensing is a licensor grants a licensee right to in tangible property to use in a specified area for a specified period of time in exchange for a fee. Franchising is a specialized form of licensing in which the franchisor grants an independent franchisee. These two kinds of foreign direct investment have been implemented by KFC for a long time.In the last 1950s Colonel Sander started to expand KFC by the franchising operation. But when PepsiCo bought the KFC, PepsiCo made a new contract for the franchisees in order to control the franchised restaurants. In the meantime, PepsiCo spent a big cash flow on buying back the week franchised restaurants. However this operation needed higher levels of investment and KFC returned on assets slowly. The investors thought PepsiCoââ¬â¢s return on assets did not match returns delivered by Coca-Cola. Therefore PepsiCo sold back the franchised restaurants. MarketingThis part will explain the marketing of KFC base on 4 Pââ¬â¢S: production, pricing, promotion and placement. Production KFC dominated the chicken segment in US. During 1990s Boston Market absorbed a lot of customers form KFC because of its roasted chicken. The Boston marketââ¬â¢s chicken was more health and its menu was more broaden which included ham, turkey, meat loaf, chicken pot pie, and deli sandwiches. So KFC introduced a new product called Rotisserie Gold in 1993. But the new product was not responded well by the customers because the customers did not like take whole chicken away. So in 1996 KFC reintroduced a roasted chicken which could be sold by piece. Pricing The pricing of KFC always was not expensive. The pricing of the product contained the taxes, excise duties, profits and the cost. Promotion Promotion is very important for the fast-food restaurants in other words you can say that promotion is the key of success. During the late 1960s, KFC was the worldââ¬â¢s famous brand image because of the promotionââ¬â¢s effect. One of KFCââ¬â¢s promotions was its Neighbourhood Program. Some restaurants offered special menu to the black community and the employees wore African-inspired uniforms. This program increased sales. Placement The placement also was essential for KFC. The sites were more and more expensive so that increased the cost and decrease the profit margins. So KFC implemented a mew three-pronged distribution strategy. Firstly KFC open the restaurants in the non traditional outlets such as shopping mail airport and railway station. Secondly KFC started to introduce the Home Delivery. Thirdly KFC and Taco BELL were restaurant co branding. In 1997 KFC restaurants added Taco Bell to the menus. So many customers came to KFC during the day. StrategiesExternal analysis KFC could not able to bring the new products to market and encountered a big setback in 1989. When KFC was experienced its sandwich, McDonald already sold its sandwich to the market. And then McDonald developed strong consumer awareness for it sandwich. In 1991 KFC supported many kinds of food to meet the customersââ¬â¢ need. These products included Oriental Wings, Popcorn Chicken, and Honey BBQ Chicken. Also KFC introduced its Neighbourhood Program. Some restaurants offered special menu to the black community and the employees wore African-inspired uniforms.This program increased 5% to 30% sales. And then KFC implemented a mew three-pronged distribution strategy to solve the problem that the sites were very expensive. Internal analysis In 1986 PepsiCo bought Kentucky Fried Chicken from RJR for 841 million pounds. Before 1986 the management of KFC was laid-back. The employees enjoyed the good atmosphere in KFC due to the efforts of Colonel Sanders to support for KFCââ¬â¢s employeesââ¬â¢ wages, pension and other non income needs. However PepsiCo change the approach to the management. PepsiCo rotated the anagers of KFC, Pizza Hut, Taco Bell, Frito lay and Pepsi-Cola through these five sectors on average every two years. One PepsiCo manager said that:â⬠You many have performed well last year, but you do not perform well this year, you are gone, and there are 100 ambitious guys with Ivy League MBAs at PepsiCo who would have to take your position. â⬠However this kind of management put too much pressure on the managers of KFC. After PepsiCo controlled the KFC, some downsizings were happened. Many loyalty employees were fired. Even the turnover of the fired managers was higher than the otherââ¬â¢s. As well as the KFC franchisees were treated badly by PepsiCo. PepsiCo made a new contract for the franchisees. According to the new contract stipulations, PepsiCo had more power to take over week franchisees and franchisees should pay more royalty fees. All the franchisees fought against the new contract because it damaged the benefit of the franchisees. The problem of the new contract was solved until PepsiCo agreed to change the objectionable parts of the new contract. PepsiCoââ¬â¢s products were divided into three markets: soft drinks, snack foods and fast-food restaurants.During the 1990s PepsiCo spent one-half annual found on the market of fast-food restaurants. But the market of fast-food restaurants only produced one-third capital every year. So the found was transferred from the market of soft drinks, snack foods to the field of fast-food restaurants. And then because of the transfer of the capital, PepsiCo was hard to compete with Coca-Cola and influenced the stock price. So PepsiCo built a new company which controlled the fast-food restaurants. Then the new company created 4. 7 billion pounds. Risk and Opportunities KFC suffered a variety of risks and opportunities in Mexico. In 1995 KFC closed all the franchised restaurants in Mexico and operated the company-owned restaurants. So KFC could provide more good quality, service and cleanness. But the company-owned restaurants needed more much money so that KFC could not expand rapidly. The peso crisis of 1995 influenced the economic in Mexico. But KFCââ¬â¢s business basically was not damaged by the inflation because mostly suppliers of KFC were in Mexico. Brazil was Lain Americaââ¬â¢s largest market. But McDonald was building first-mover advantages and KFC even had implement business in Brazil. KFC planed to expand into the economic market in Brazil.In Latin America KFC was more aggressively building franchised restaurants in order to build KFCââ¬â¢s brand. Conclusion and Recommendation According to the discuss and analysis, KFC should solve immediately the internal management problems to change the high performance, high accountability, highly driven culture and create a happy atmosphere that all the employees work comfortable in. PepsiCo could build more company-owned restaurants. It is easy control the Quality, Services and Cleanliness to improve the band image. Also KFC should open the restaurants in Latin America where is a large untapped market.KFC could develop the online shopping system that customers could buy products in the internet and delivery to the home. All in all, KFC is the second largest fast food restaurant. It is a successful enterprise and still is able to potential development. PepsiCoââ¬â¢s culture should better integrate into the KFC in order to increase the competitive and provide more health and better products to the worldââ¬â¢s people. Reference Jeffrey A. Krug case34 Kentucky Fried Chicken and the Global Fast-Food Industry ââ¬Å"KFC Corporation. â⬠International Directory of Company Histories. 2008. Encyclopedia. com. 1 April. 2012
Thursday, March 19, 2020
An Investigation into Species Diversity essays
An Investigation into Species Diversity essays An Investigation into Species Diversity at Lake Alice, Florida; The Effect of Island Size and The Impact of Human Disturbance on Species Number and Diversity The main objective of this investigation is to determine the effect of island size and human disturbance on the diversity and general population size of birds living in and around Lake Alice. The null hypotheses for this experiment would suggest that (i) human disturbance does not have a detrimental impact on species number or diversity in Lake Alice and (ii) Island size does not effect in any way the number or diversity of birds in Lake Alice. Binoculars were used to locate and record individual species type and frequency over twenty minutes. A human count was also taken to show disturbance (if any). A tape measure was also used to measure the approximate size of each island and its distance from the shoreline. The results collected disproved the null hypothesis; showing that human disturbance (in terms of people number and distance from the shoreline) did in most cases lead to a decrease in species number and diversity in contrast to relatively undisturbed islands. This was shown using numerical values from the Sharon Index. Studies such as the flowing, are important for making inferences about the impact of bird number and diversity, not only in designate d areas (such as lake Alice) but the whole world also. Conservation and management strategies can therefore be inferred using studies such as this for the most affective and appropriate course of action for environmental sustainability (Rundle D. 1991). Interspecific competition: competition between different species for a resource. E.g space. Intraspecific competition: competition between members of the same species for a resource. Eg. Space Biodiversity: the existence of a wide range of different types of organisms in a given place at a given time. Habituation: occurs wh...
Monday, March 2, 2020
How to be a Welcome Guest Poster
How to be a Welcome Guest Poster Posting on guest sites is a great way to increase your profile, develop your personal brand ââ¬â and subtly plug a product or service. Heres how to increase your chances of getting your posts accepted Writing guest posts is a great way to promote your work and build your personal writers brand. Ive done a lot of this recently, to promote my book, Kitten on a Fatberg. Ive spent quite a lot of time sending off ideas, reading submissions guidelines, and liaising with editors. Here are some of the things Ive learned along the way Have something to sayà Start Look for topics that are editorial in nature but aligned with your product. My book is a comic novel written with two co-authors, for example, so Ive pitched various ideas to do with writing humour, crowdfunding a novel, collaborating on a book and so on. Research your marketsà Its important to make sure theres a good fit between what you want to say and where you might be able to post it. A sci-fi forum may publish lots of guest posters, for example, but if youre a chick-lit author youre probably unlikely to become one of them. You may have a great piece about a popular topic such as productivity or writers block to offer, but if the site has already covered this area extensively, youll probably be unlucky there too. Turn topics into ideasà When presenting ideas, try to entice your editor with a real attention-grabbing headline and a standfirst ââ¬â that catchy intro para that magazines and newspapers use to lure people into reading the full article. Then, even if you are addressing a popular topic, you can show you have a unique angle on the topic, and you may be in luck. So rather than offering the dull and generic-sounding Top productivity tips, try 7 ways to slay your inner procrastinator, followed Keep it personal Dont blast out the same email to a big list of blogs and websites. Send out a few at a time, personalizing each one, with a brief intro about who you are (which you might also want to tweak each time). Focus on why your ideas might be of interest to readers, get recipients names right, and always Follow the guidelines The biggest bugbear of writing blogs is, quite understandably, submissions from people who havent followed their guidelines. These are always supplied clearly and in lots of detail, so it will seem quite discourteous to an editor if you ignore their requests about formatting, imagery, subject matter, word count, use of links, etc. Some popular blogs will simply reject your ideas or submission out of hand if the guidelines havent been followed. Do as youre told! Editors will almost always want to make a few tweaks to your words. They may want some additional copy from you or ask for words to be cut. They will very often tweak the intro and opening section to make it sit better with their style and approach. Remember editors know their markets and their titles inside out, and if they want some tweaks, it means they want to publish you very soon. So, this is no time to be precious about your writing ââ¬â go with their editorial decisions and turn any requested amends round asap. Final thought: Keep the promo stuff to a minimumà Theres a quid pro quo in guest posting ââ¬â you give the editor some content of value, and theyll let you plug your book. But dont overdo the promotional element ââ¬â if your piece is crammed full of references to your book, it will just come across as one big advert, and it wont be accepted. Writing something thats useful or entertaining for people is the best advertisement for your work, after all.
Saturday, February 15, 2020
English as Only US Official Language Essay Example | Topics and Well Written Essays - 2000 words
English as Only US Official Language - Essay Example Other like-minded movements followed but none has so far prospered because of the chief argument that an attitude of intolerance towards languages other than English is undemocratic and impinges on individual liberties. The policy has nonetheless gained headway in at least 27 states, where pro-English laws or resolutions have already been enacted. On the federal level, two opposing lobbies have been organized represented by the English Plus movement that pushes for bilingualism, and the English Only group that clamors for monolingualism and for English to be declared as the only official national language. This paper dissects the pros and cons of the issue and evaluates which side makes more sense and a stronger case. Topic Sentence 2 - Spanish is perceived to be the biggest threat to English since Hispanics comprise the largest number of immigrants in the US, such that more and more public utilities and documents are inscribed in Spanish especially in areas where there are large immigrant communities. There are over 300 languages spoken in the US by people whose primary language is not English, but Hispanic immigrants easily qualify as the largest group of non-English speakers because of the proximity of the US to Latin America. According to the US Bureau of Census, in a tone that suggests warning, 100 million people of Hispanic origins will be all over the 50 states of the Union by 2050 (Lynch 11). Because of this large-scale immigration of Hispanics, Spanish has become the unofficial second language of the US (Rodriguez 3). This bothers Americans with native roots that perceive the growth of Spanish-speaking communities as a threat to English. Why is this predominantly used immigrant language in America considered a threat to English Rep. Tom Tancredo (R-Colorado) explains that Spanish is making inroads into the predominant position that should be occupied by English among Americans. This is duality that must be avoided at all costs because "it would weaken American identity an d sow the seeds of disunity and conflict." The possible weakening of the American identity and the potential of bilingualism to breed disunity is the battle slogan of such organizations as the English Only movement, Official English and the US English Inc., the latter a political lobby group founded by the late Senator from Alaska Samuel Hayakawa and Dr. John Tanton in 1983. These groups feel that English is losing out to Spanish and call for federal legislation to declare English as the official language, specifying that no other state law or policy shall be enforced that requires the use of any language other than English. English Only advocates point to Hartford in Connecticut to show that English is retreating in favor of Spanish and that the threat is real (Mujica 5). Hispanics comprise 40 percent of the population of this typical American city, where half of its Spanish-speaking people do not speak English at all so Spanish is the
Sunday, February 2, 2020
Kerouac and Moon Essay Example | Topics and Well Written Essays - 750 words
Kerouac and Moon - Essay Example These two people are Dean and Sal. In the course of their journeys around New York, there are several fascinating encounters the two friends come across that both enlightens their views and opinion about the American person and also gives them a peculiar identify of where they two of them also belong in the American society or system. On his part, Heat-Moon William Least in writing Blue Highways takes the story from the perspective of someone who is not meeting love right away but bitterness and pain. This was because the journey that is described in this book was embarked upon by someone who had just separated from his wife and also lost his lost. As a way of finding solace from not just the brighter side of life but the ugly part of it also, the voyager decides to travel along the rural part of America that is often marked by a blue line in Rand McNally road atlas and thus the Blue Highway. It could briefly be said that both works are similar because they are all based on journeys of the life of real people while the setting of the journeys and the causes of the journey brings out the differences in the two books. Likes among both writers Both authors exhibit in their writing and the narration of their journeys, certain things they like about America that are common in both instances. One of these is the seemingly clear love for alcohol. This is shown because Kerouac emphasizes his love for big party with alcohol (Kerouac, p. 53). Similarly, Moon reiterates his love to drink a lot of alcohol (Moon, p. 6). Clearly, reasons as to why these two writers both love the abundance of alcoholic drinks in America could be traced to the circumstances surrounding their trip. On the part of Kerouac, it could be said that he was just putting himself in the most common kind of mood that new friends and lovers put themselves in, which has to do with the sharing of drinks and alcohol to make themselves feel so good. On his part, Moon might have taken to the love for alcohol a s a way of dealing with the pain and grief that his heart bore. The love for alcohol is thus similar among the two writers but the reasons for liking alcohol is quite different. Both writers also exhibit their likeness for music and dancing. Though Moon traveled through the rural part of America and Kerouac travelled through New York, it is common to find that music and dance is something that is synonymous with all parts of America being it rural or urban. This is because while Kerouac who was in the heart of the city wrote that he loves music and dance (Kerouac, p. 53), Moon who was also in the rural setting also wrote that he loves to enjoy his life by dancing off his stress (Moon, p. 9). Regardless of this similarity however, it can be said that the sources of enjoyment that came with music and dance for the two writers were different. For instance in the city, one is likely to party in places like the discotheque or club while in the rural area, all that there is to offer are p ubs and little bars and restaurants. Again, there exist differences in terms of causes of action. This is because while Kerouacââ¬â¢s action was caused by the desire to make himself happy with his friend, Moonââ¬â¢s action was caused by the need to throw off his sorrows. Dislikes among both writers As normal people, it would not be every single thing that these two individuals see about America that they will love. This is especially so as the two had to travel around different places in America. Indeed once a person is travelling around; it is common that he fellow will come across different people and different events that will trigger the personââ¬â¢
Saturday, January 25, 2020
US foreign Policy 1865-1914, expansionist or isolationist Essay
Was the foreign policy of the United States primarily isolationist or expansionist through 1865-1914? Ã Ã Ã Ã Ã At the turn of the century, and after gaining our independence, the United States land mass more than doubled through the use of purchasing, annexing, and war. However, the foreign policy of our government took a predominately isolationist stand. This was a national policy of abstaining from political or economic relations with other countries. General Washington shaped these values by upholding and encouraging the use of these principles by warning to avoid alliances in his farewell speech. The reasoning behind these actions was that the Republic was a new nation. We did not have the resources or the means to worry about other countries and foreign affairs; our immediate efforts were internal. Our goals that were of primary importance were setting up a democratic government and jump-starting a nation. The United States foreign policy up to and directly preceding the Civil War was mainly Isolationist. After the war, the government helped bring together a nation t orn apart by war, helped improved our industrialization, and helped further populate our continent. We were isolationist in foreign affairs, while expanding domestically into the west and into the north through the purchase of Alaska. However, around 1890 the expansionism that had taken place was a far cry from what was about to happen. Expansionism is the nations practice or policy ...
Friday, January 17, 2020
Make Cigarettes Illegal
One of the largest and most problematic health issues in our society is smoking. Smoking is currently the leading cause of death in our country, due to its harmful and addicting contents, such as nicotine. Although millions die from it each year, smoking is the single most preventable cause of death. Since there is such a high number of deaths, enormous numbers of smoking related diseases, and damage to planet earth, smoking should be made illegal. The first reason smoking should be illegal is because it is detrimental and an addicting drug, just like many illegal ones. Methamphetamine, and crack are some of the most dangerous drugs to use but what many people do not know is Nicotine is just as harmful. According to a chart in Health and Wellness, experts rate on how easy it is to become addicted and how difficult it is to quit. Using various drugs, 100 is the highest addiction potential. Number one on the chart for being most addictive was Nicotine with a score of 100 for having the most addiction potential. Number two was Methamphetamine(smoked) with a score of 96. Number three was Crack with a score of 94. Number 4 was Methamphetamine (injected) with a score of 90. Of the 4 top addictive drugs listed, all are illegal except Nicotine. Nicotine has a much higher death and addiction rate than both meth and crack put together, yet nicotine and cigarettes are still legal. Another reason smoking should be illegal is 50,000 people die each year due to second hand smoke. Is it fair that people who do not smoke are forced to breathe in the chemicals of cigarettes? Is it fair that people who do not smoke are struck with smoking related diseases? Many people believe that solving the problem could be as simple as prohibiting smoking in public places. It does seem to make sense but when you think it out thoroughly, it is not nearly solving any problem. Yes, the number of second hand smoke related deaths would decrease but would not be eliminated. People in public would not have to worry about cigarette smoke but who would? Children. This law would be forcing them to live in a house full of smoke. Yes, the number of second hand smoke related deaths would go down but this law would increase the number children dying or suffering from cigarette smoke. As of today, americanheart. org states that aboutà 60 percent of American children ages 4ââ¬â11 are exposed to secondhand smoke at home. Studies have shown that children (especially infants) of parents who smoke have more lung illnesses, such as bronchitis and pneumonia, and can develop asthma. What is that percentage going to be when the only place smokers can smoke is home? Children from ages 4-11 are not the only ones suffering from this drug. Unborn babies are greatly affected by cigarettes. How could any expecting mother put their baby at risk for any damage to their innocent, undeveloped bodies. It is completely unethical and disgusting that something so dangerous to an unborn baby is legal! TheTruth. rg states that every single year smoking durning pregnancy and exposure to second hand smoke results in the death of 776 infants and unborn fetuses every year. That is 776 too many! Other than death, there are many other complications that come with smoking during pregnancy . Low birth weight, premature birth which can cause learning disabilities, cerebral palsy, and mental retardation. Marchofdimes. com held a stu dy that showed women who smoke anytime during the month before pregnancy to the end of the first trimester are more likely to have a baby with birth defects, particularly congenital heart defectsà . The risk of heart defects appears to increase with the number of cigarettes a woman smokes. Expecting mothers should not even have this option because smoking should be illegal. Besides babies, here are some problems that come along for anyone who is exposed to cigarette smoke. â⬠¢Reduces fertility â⬠¢Increases likelihood of impotence â⬠¢Contributes to thin bones â⬠¢Affects mental capacity and memory â⬠¢Reduces levels of folate, low levels of which can increase the risk of heart disease, depression, and Alzheimer's disease â⬠¢Affects ability to smell and taste â⬠¢Increases risk of depression in adolescents Increases risk of heart disease, stroke, high blood pressure â⬠¢Increases risk of diabetes â⬠¢Increases risk of cancer â⬠¢Causes breathing problems â⬠¢Reduces immune system and get colds and flu more easily ( http://healthliteracy. worlded. org) I think by now, it is pretty obvious that cigarettes are very unhealthy. What is it exactly th at make them unhealthy? Almost everything in them! according to healthyliteracy. worldwide. org There are over 4,000 chemicals in cigarettes. 51 of them are known to be carcinogenic. A carcinogen is something that causes cancer. Cancer is a disease that often kills those who have it. Chemicals in cigarettes and cigarette smoke are known to cause not only cancer but also other serious health problems. Many of the chemicals are poisonous. If a person ate one pack of cigarettes, he/she would die. Some of the familiar chemicals in cigarettes are- Carbon Monoxide which is found in car exhaust. Nicotine, a strong poisonous drug. It is the main ingredient in bug sprays. In its pure form, just one drop on a person's tongue would kill him/her. Tar, a material to make roads. Arsenic, rat poisoning. Ammonia, which is cleaning products. Hydrogen Cyanide, gas chamber poison. Cyanide, deadly poison. Acetone, nail polish remover. Butane, cigarette lighter fluid. DDT, insecticides. Formaldehyde, fluid used to preserve dead bodies. Sulfuric Acid, in car batteries. Cadmium, Used to recharge batteries. Freon, damages earths ozone layer. Maltitol, a sweetener not permitted to be used in foods in the U. S Although America is a free county and many people believe that smoking is a choice of freedom, there should be no freedom in killing yourself and others. Some people would argue that smoking should not be illegal because there are many things a person can do that are just as dangerous. For example, skydiving. While skydiving may dangerous, it is not the number one most preventable cause of death in America. Yes, an activity such as skydiving is taking a huge risk of danger but it is not guaranteed that you will get sick or die. Skydiving is regulated to make sure the health and wellbeing of a diver whether professional or non professional does not perish when attempting to jump. As for cigarettes there are no state or federal regulations that protect you or help you from disease or death. With all of this being said, I strongly believe that there is no need for such a deadly product that is useless in todays society.
Wednesday, January 8, 2020
Rome and Its Lasting Impression on the World - 1538 Words
The Roman Empire and Its Influence on Western Civilization Rome s vast empire lasted for an amazing one thousand-year reign. Half of it referred to as the republic, and the other as the empire. However, after its fall in 5oo-a.d. Rome has still remained in existence through its strong culture, architecture, literature, and even religion (Spielvogel 175). Even after its disappearance as a nation Rome left behind a legacy that will never be forgotten. Its ideals and traditions have been immolated, and adopted for over two thousand years. Whether, it is through its language of Latin, its influence of religion, or its amazing architectural ability Rome has influenced almost every culture following its demise. The heritage of Rome hasâ⬠¦show more contentâ⬠¦coliseum, and the circus maximus) which could be compare with the sports arenas of today. In appearance our stadiums of today are not exactly the same, but one can see the similarities in them. Take the coliseum, this st adium is huge, and was built for one purpose; and that was to hold as many Romans as possible. Today s stadiums are the same way. They are huge, marvelously constructed buildings that are meant to hold thousands of people. Also, the coliseum and circus maximus were built for the people to watch games or sporting events, just like today. Whether it is a football game at the Silverdome, or a group gladiators fighting to the death in the coliseum, it is all meant to house entertainment. Roman architects would also build grand public buildings, which were the center of Roman social life. These popular places were the public baths or malls, as they would be called today. These buildings had every anything from libraries to shops. They were huge covering about thirty-three acres of land, and were always crawling with Romans, both rich and poor (Hadas 87). These are very similar to the Malls of today. Both are places where people enjoy spending a large amount of time at, and at he same time can be entertained. Grant it, the malls of today do not contain public bathing areas, as did the Roman malls (except for certain places in California, but they have been closed down for at least 15 years). However,Show MoreRelatedThe Greatest Accomplishments of the Pax Romana?1214 Words à |à 5 Pagesthese achievements was the peace and stability they achieved. During the extended peace, Romes architecture flourished. The architecture glorified Rome and was extremely advanced during the time period. Rome designed and built large, amazing architectural structures. They had great success and built many glorious buildings like Pantheon and the Colosseum. Both of these structures were extremely beautiful and also contributedRead MoreEssay on Roman Influence on Byzantine Empire and Islamic Societies1584 Words à |à 7 PagesMother of the World ââ¬Å"The mother of the world has been killed,â⬠stated a 5th century historian, bereft and appalled when the news of Romeââ¬â¢s fall had reached ear. Certainly his words hold truth, for Rome - the dauntingly colossal Empire engulfing the Mediterranean and all territories around it; the source of artistic, intellectual, and cultural ascendancy; the influential factor of brilliance in so many of the coexisting societies of the western world - was truly the predecessor and creator of allRead MoreItaly: Top Touristic Destination1249 Words à |à 5 PagesItaly. Itââ¬â¢s known for its history, attractions, food and language. Italy is a Mediterranean country in the south of Europe. Itââ¬â¢s also divided into 20 regions. Italy is the fourth largest tourism, fifth most visited country. It has many mountains and has few plains. Therefore it is similar to the dessert, hot and dry. The Italian flag has three colors Red, White, Green. Each one has a meaning. The Green Represents hope, White is faith and red represents charity. Italy capital is Rome, locatedRead More Brief History of Tour Guide1110 Words à |à 5 PagesGuiding is one of the oldest professions of the Western world. The evolution of tour guides and the guiding history was divided by Pond (1993) into four periods. There are plenty of specific references in the annals of history, from the Roman Empire to the Middle Age, throughout the renaissance and into the Modern Age. Tourism saw the first major development during the era of the great empires. (3000 B.C. to A.D.500) During this period travelling is dangerous and time consuming. The ancient PersiansRead MoreThe German Stereotype Of The United States1621 Words à |à 7 Pageseffect how the Germans were accepted and viewed in the United States. Different times and issues have changed how Germans were viewed in America, for example both world wars and the following strong anti-German stance. While these times of strong emotion often change peopleââ¬â¢s outlook, I would argue that the p ositive or more neutral impression of German immigrants compared to other immigrant groups, helped Germans settle in America. While times of strong emotion often change peopleââ¬â¢s outlook, German immigrantsRead MoreEssay about Cultural Awareness the Country of Italy1983 Words à |à 8 Pagesthe growth of what was to become an empire. Around 45 BC, Julius Caesar becomes the first dictator of Rome defecting Pompey to take control of the empire. Later during his reign, his own people assassinate Caesar, which leads to a trio of charters that history would come to know as Marc Anthony, Octavian and Lepidus, Octavian would later defeat the other two and become known as Caesar Augustus. Rome would even conqueror Egypt and all this before the birth of Christ. Whose life was during Roman ruleRead MoreThe Theme of Julius Caesar Essay2961 Words à |à 12 PagesA dish fit for the gods ââ¬âJulius Caesar and the expression its Greek to me have all become catch phrases in modern day speech. Furthermore, other William Shakespeare quotes such as to thine own self be true have become widely spoken pearls of wisdom. As he was valiant, I honor him; but, as he was ambitious, I slew him . - (Act III, Scene II). Not that I loved Caesar less, but that I loved Rome more. - (Act III, Scene II). Cowards die many timesRead MoreTaking a Look at Landscape Paintings1821 Words à |à 7 Pagesââ¬Å"Any landscape is a condition of the spirit.â⬠- Henri Frà ©dà ©ric Amiel Itââ¬â¢s more often the unknown that causes us to ask questions. Landscape paintings have always had a feeling of ambiguity and mystery to them. Unlike paintings with historical or classical subject matter, landscapes donââ¬â¢t always have a clear narrative or meaning. Instead of providing the viewer with answers, they will often provoke more questions. A historical painting like ââ¬ËLiberty Leading The Peopleââ¬â¢ gives us a clear narrativeRead MoreGap Inc. Essay2132 Words à |à 9 Pageswhich serves as a high profile high budget Gap Inc. store. Gap Inc. To the eyes of Don and Doris Fisher opening the first store was more than just selling jeans; it was to serve the people and to gain integrity. They also wanted to create a lasting impression to the consumers. This has become the mission statement for Gap Inc. and has stuck with them ever since they opened their first store. Gap has broadened their products from the jeans that Doris and Don could not fit and made to the countlessRead MoreAn Analysis Of The Happiness Hypothesis By Jonathan Haidt1883 Words à |à 8 Pagesit (Haidt 9). This third conflict is of Old vs. New but discusses the conflict of emotion and rationality. In patients with damage to orbitofrontal cortex, which regulates and produces emotions, they become very rational but also crumble in a real world setting, without having any personal, emotion drive (Haidt 12). This shows that reason and emotion are both necessary for the functioning of the human mind, the cooperation of both rider and elephant is necessary. The last conflict is that of the automatic
Tuesday, December 31, 2019
The World Of Genetic Engineering - 1968 Words
A large majority of Homo sapiens do not appreciate the existence of bacteria, as evinced by the myriad hand sanitizer bottles ubiquitous in daily life, boasting, ââ¬Å"Kills 99.9% of germs.â⬠This is a highly rational response to the group of microscopic organisms, of which it is true many are malignant to maintaining homeostasis as agents of disease. However, bacteria are essential to the worldââ¬â¢s functioning, with important roles and many benefits. Recently, scientists studying certain bacteria have found a mechanism in their immune systems that can alter the very code of life, deoxyribonucleic acid (DNA). This new tool is called Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), and has revolutionized the world of genetic engineering. CRISPR/Cas9 is less expensive, more accurate, and more effective, making this method much more amicable and available to the common geneticist compared to former techniques such as Transcription Activator Like E ffector Nucleases (TALENs) and Zinc-Fingered Nucleases (ZFNs). This availability and potential applicability to the human genome raises important questions about ethics and modification of subsequent generations of humans. CRISPR has brought bioethicists and scientists together to demarcate the limits of genetic modification. Most agree aberrations to the human race as a whole may result in unforeseeable and irrevocable effects. Although genetic engineering performed on human beings is indubitably an avenueShow MoreRelatedApplication Of Genetic Engineering On The World1606 Words à |à 7 PagesApplication of Genetic Engineering on Taro Adam Mohamed 10/23/2015 Introduction The field of genetic engineering is very promising, pertaining to the future of agriculture around the world. Research in this area is allowing for more and more improvements to the various aspects of a crop such as yield, visual quality, taste, nutritional value, disease immunity, and cold resistance, as well as many other benefits. A further understanding of both the genetics of crops and how to influenceRead MoreGenetic Engineering: Brave New World1012 Words à |à 5 PagesGenetic engineering has been around for many years and is widely used all over the planet. Many people donââ¬â¢t realize that genetic engineering is part of their daily lives and diet. Today, almost 70 percent of processed foods from a grocery store were genetically engineered. Genetic engineering can be in plants, foods, animals, and even humans. Although debates about genetic engineering still exist, many people have accepted due to the health benefits of gene therapy. The lack of knowledge has alwaysR ead MoreGenetic Engineering and a Brave New World1694 Words à |à 7 PagesGenetic Engineering is one of the current hot button topics of our world today and its also the fundamental theme in widely know novels such as Brave New World and My Sisterââ¬â¢s Keeper. But what exactly is Genetic Engineering? What exactly does Genetic Engineering entail? Genetic Engineering in its self is a mammoth and board field, yet not many people actually know or even understand the diversity that Genetic Engineering entails. When most people perceive the slightest sound of the word GeneticRead MoreGenetic Engineering : A World Where Autism And Downs Syndrome1270 Words à |à 6 PagesGenetic Engineering Imagine a world where autism and downs syndrome are a thing of the past, and where there is no shortage on food for anybody. Over the years mankind has developed and improved technology to save more and more lives through the manipulation of the DNA that makes up all living organisms. However, there are those who oppose this approach. Despite the risks and ethical concerns, genetic engineering holds the potential to benefit humanity through both direct and indirect means. InRead More Genetic Engineering and the End of the World As We Know It Essay1405 Words à |à 6 PagesIts The End Of The World As We Know It (And I Feel Fine) --- From a Song by REM Having completed the Human Genome Project, scientists now seek to uncover the secrets of the human proteome (Begley 1). It is guesstimated that the proteome, meaning all the proteins, will involve up to 1000 times more data than the genome did. But this again brings us to the question: What will the scientific and medical communities do with all this information? deCode Genetics, partnered with Roche HoldingRead More Genetic Engineering: Our Key to a Better World Essay1128 Words à |à 5 Pages What is genetic engineering one might ask and why is there so much moral controversy surrounding the topic? Genetic engineering as defined by Pete Moore, is the name given to a wide variety of techniques that have one thing in common: they all allow the biologist to take a gene from one cell and insert it into another (SS1). Such techniques included in genetic engineering (both good and bad) are, genetic screening both during the fetal stage and later in life, gene therapy, sex selectionRead MoreEssay on Genetic Engineering Can Be Beneficial in the Modern World1924 Words à |à 8 Pageshave now applied what they have learned in the study of genetics to help modify and improve the properties of plants and organisms that we can benefit greatly from. Genetic engineering can be beneficial for humanity in the modern age as they are considered safe, able to support the demand of resources by the ever-increasing human population, and provide potential cure to many incurable diseases and p ossible life extension. Genetic engineered products that have been approved for use in theRead MoreGenetic Engineering in Donny and Ursula Save the World by Sharon Weil666 Words à |à 3 Pagesgoes onâ⬠(Robert Frost). People from the beginning of civilization have cultivated crops ranging from methods of fermentation to classical selection for desired traits. In essence, genetic modification is not a new concept only conceived in the twentieth century; it has been occurring for millenias. Genetic engineering is only a step forward as the latest form of gene selection utilizing biotechnology, which merely catalyzes processes that previously required generations upon generations to that ofRead MoreAn Enhanced Genotype: Ethical Issues Involved with Genetic Engineering and their Impact as Revealed by Brave New World2301 Words à |à 10 PagesEnhanced Genotype: Ethical Issues Involved with Genetic Engineering and their Impact as Revealed by Brave New World Human society always attempts to better itself through the use of technology. Thus far, as a species, we have already achieved much: mastery of electronics, flight, and space travel. However, the field in which the most progress is currently being made is Biology, specifically Genetic Engineering. In Aldous Huxleyââ¬â¢s Brave New World, humanity has taken control of reproduction and biologyRead MoreBenefits Of Genetically Engineered Food1240 Words à |à 5 PagesThe alteration of plant and animal genetic codes for the ultimate purpose of increasing food abundance is an increasingly popular, yet controversial practice in the 21st century. Genetic engineering of food is done for a number of reasons, the biggest of which is increasing food supplies in the world, especially for the third world countries. However, there are arguments and even activist movements against genetic engineering of food, which begs the question ââ¬Å"why is genetically engineered food so
Monday, December 23, 2019
Library Management - 1847 Words
Stephanie Library Management The creation of library management is crucial for any type of libraries that wish to work effectively in the ever changing environments. With elements like worker efficiency, introduction of technology, and the changes of cultural environment managers are always looking for ways to create an efficient environment for their workers as well as those they serve. When it comes to management systems, there are two different types that are examined in this paper. These type models include the Luther Gulickââ¬â¢s POSDCORB, as well as the Mintzbergââ¬â¢s managerial model. While examine these models, there was also comparison done to current library management. Are these two models still in use, or has the uses of theseâ⬠¦show more contentâ⬠¦After much deliberation, the chosen methodology to effectively examine the manger to see whether these models are still used was a combination of two different aspects, which are the observation and the interviewing technique. Observation wa s chosen since the examinee had easy access to the chosen manager, and proved to most reliable for firsthand examination of these models. The interview process was also chosen on the premise of the time table of observation could possibly not process most of the elements that both of the chosen models required. The manager was observed from afar for a span of a week, from thirty minutes to an hour each day. This technique was chosen to most effective since by spreading out the observation times, the manager would more than likely be engaged in different aspects of these models and provide more varied data. This technique was also chosen because it was less obtrusive for the manager and flexible for the examinee when gathering data. Those elements that werenââ¬â¢t seen through observation were discussed in the interview process at great length. Analysis of data collected Analysis of data :collected Week of October 18/22 The observation phase of the research was highly successful when examining the number of ways the manager handled a number of situations internally andShow MoreRelatedLibrary Management System1779 Words à |à 8 PagesStudy 7.2 Conclusion and Justification Chapter 8 8.1 Recommendation 1.1 Introduction The LIBRARY MANAGEMENT SYSTEM is a data processing to perform routine Library activities. This system is concerned with developing a library management system using visual basic. In this system the library management becomes more efficient and easier to handle with its reliable system components. Library system was developed in order to make computerized the borrowing and returning of books, return booksRead MoreLibrary Management204752 Words à |à 820 PagesLibrary and Information Center Management Recent Titles in Library and Information Science Text Series Library and Information Center Management, Sixth Edition Robert D. Stueart and Barbara B. Moran United States Government Information: Policies and Sources Peter Hernon, Harold C. Relyea, Robert E. Dugan, and Joan F. Cheverie Library Information Systems: From Library Automation to Distributed Information Access Solutions Thomas R. Kochtanek and Joseph R. Matthews The Complete Guide to AcquisitionsRead MoreLibrary Management System6342 Words à |à 26 PagesValeriano Fugoso Public Library Integrated Library System A Case Study Presented to the Department of Information Computer Studies Faculty of Engineering University of Santo Tomas In Partial Fulfillment of the Requirements in Database Management Systems October 2010 Title Page Table of Contents 1. Introduction. 2. About the Company 1. Background and History 2. Organizational Chart 3. Contact Person/s 3. The Current System 1. DetailedRead MoreQuality Management in Academic Libraries Essay1288 Words à |à 6 PagesQuality management has been extensively applied within the manufacturing industry over a decade. later, the service industry has increasingly emphasized this area. Quality management is increasingly integrated into library services, following their perceived success in manufacturing industries with particular emphasis on improving service quality. Since manufacturing industries differ in terms of the characteristic quality, different criteria must be used for measuring these industries. Quality managementRead More Management Study at a Library Essay examples2401 Words à |à 10 PagesIntroduction Management, as defined by Daft and Marcic, is the effective and efficient attainment of organizational goals, through planning, organizing, leading and controlling organizational resources. This community service organizational study has allowed our group to extend our learning outside the classroom and apply management theories to the real world. The site that we volunteered at was the Venice Library. Upon first arriving, our team thought that it was going to be a struggle to tryRead MoreMy Personal Philosophy On Library Management1983 Words à |à 8 PagesBettina Scales Dr. Abdullahi LSIS 5120 November 1, 2014 My Personal Philosophy on Library Management Within the library profession, a key component is management.Proper Management is vital for successful libraries.I think library managers must possess qualities of friendliness, vision, approachability, and decisiveness. As a future archivist, of a museum or school library like Shepard Library, I would want to be a leader that embodies these qualities. Along with great qualities, I would need toRead MoreData Management And The Library System1591 Words à |à 7 Pages Data management in Libraries Iteration 1 Snowy Osahan Wilmington University Table of Contents Iteration 1: Orientation to Inspiration Space 3 Plan 3 Action 5 Observation 6 Reflection 7 References 9 Iteration 1: Orientation to Inspiration Space The orientation session will be conducted for the interns at Inspiration Space for a period of two days. During this phase, the interns will be introduced to the employees of Inspiration Space and the library that are associatedRead MoreProject Management Library Renovation2266 Words à |à 10 PagesProject management principles Project management principles are typically learnt from experience and are generally valid for all projects and the project manager has to know when and how to apply them to a project (Harold, 2009). In the library building project these principles could have helped reduce problems during and after renovations of the library. Tailor to suit the environment: whatever project management methodology or framework a manger favours, it must be tailored to suit the needsRead MoreAcademic One File of Lyceum of the Philippines University Library as Perceived by the Selected Student of College of International Tourism and Hospitality Management2242 Words à |à 9 PagesACADEMIC ONE FILE OF LYCEUM OF THE PHILIPPINES UNIVERSITY LIBRARY AS PERCEIVED BY THE SELECTED STUDENT OF COLLEGE OF INTERNATIONAL TOURISM AND HOSPITALITY MANAGEMENT A thesis presented to the faculty of College of Arts and Sciences Lyceum of the Philippines University In partial fulfillment of the requirements for the degree of Bachelor of Science International Hospitality Management with specialization in Cruise Line Operation in Hotel Services Mary Angelie M. Andres Dan Paolo M. Asuncion KarenRead MoreQuality Management System For Coventry University Library2593 Words à |à 11 PagesThe `Know IT` (Knowledge intergration ) quality management system for coventry university library Introduction Higher education intuitions have always resisted total quality management, quality management systems were perceived as incompatible with the academic culture. However, universities have become market driven, so in order to compete on a global scale and attract international students, they had to establish quality management systems to set themselves apart from the competition. It has
Sunday, December 15, 2019
Parkinsons Disease Free Essays
string(47) " that target the neurotransmitter systems \(e\." PD normally affects people over the age of 50. It becomes more common with increasing age. ââ¬ËAbout 5 in 1,000 people in their 60s and about 40 in 1,000 people in their 80s have PDââ¬â¢1. We will write a custom essay sample on Parkinsons Disease or any similar topic only for you Order Now It affects both men and women but is a little more common in men. PD is not usually inherited, and can affect anyone. However, genetic factors may be important in the small number of people who develop the disease before the age of 50. PD therefore affects a lot of people in the UK and I have chosen this topic so I have a greater understanding of what they go through and how we can help those affected. Background: Biology of Parkinsonââ¬â¢s disease? Parkinsonââ¬â¢s disease is a chronic disorder of part of the brain called the substantia nigra. It mainly affects the way the brain co-ordinates the movements of the muscles in various parts of the body. This area of the brain sends messages down nerves in the spinal cord to help control the muscles of the body. Messages are passed between brain cells, nerves and muscles by chemicals called neurotransmitters. Dopamine is the main neurotransmitter that is made by the brain cells in the substantia nigra1. Muscular System: Muscle Metabolism iframe class="wp-embedded-content" sandbox="allow-scripts" security="restricted" style="position: absolute; clip: rect(1px, 1px, 1px, 1px);" src="https://phdessay.com/muscular-system-muscle-metabolism/embed/#?secret=XWYQr2myDT" data-secret="XWYQr2myDT" width="500" height="282" title="#8220;Muscular System: Muscle Metabolism#8221; #8212; Free Essays - PhDessay.com" frameborder="0" marginwidth="0" marginheight="0" scrolling="no"/iframe In PD, cells in the substantia nigra are damaged and die. The cause is unknown. Over time, more and more cells become damaged and die. The more cells that are damaged the less dopamine is produced. The reduction of cells and the low level of dopamine in the cells in this part of the brain causes nerve messages to the muscles to become slowed and abnormal1. In the long term PD will ultimately lead to death. Causes We are still unsure of the causes of PD but here are the most likely and most talked about suggestions: 1. The hereditary form of PD occurs in fifteen per cent of cases2. The genes affected help clear nerve cells of excess proteins. Scientists are not sure but it is thought that when the ââ¬Ëproduction process for protein manufacture breaks down, little clumps of ill-formed proteins begin to accumulate in cellââ¬â¢ 17, causing cell death. Tests carried out on rats using rotenone imply that pesticides and toxins may lead to PD. The rats experienced shaking and a loss of muscle control as well as developing Lewy bodies (spherical lumps found in dying brain cells), which are commonly associated with Parkinsonââ¬â¢s disease. However, researchers are yet to find evidence for any definitive link to a particular toxin or drug in humans. 2. There seems to be a link between variants of the mitochondrial genes and PD. The Parkinsonââ¬â¢s Disease Research Agenda states that ââ¬Å"mitochondrial dysfunction has numerous consequences, including energetic failure, generation of reactive oxygen species, disregulation of calcium homeostasis and induction of apoptosis, each of which may be important in Parkinsonââ¬â¢s diseaseâ⬠3. 3. High concentrations of free-radicals in the body and a lack of antioxidants. Free radicals damage cells and if too many dopamine-producing cells were damaged then this could lead to PD. Antioxidants prevent the production of free radicals and repair damage done by them. Symptoms and effects There is no easy test to diagnose PD, so it is diagnosed by ruling out other diseases and looking for the classic symptoms: * Slowness of movement (bradykinesia)1. It will become more of an effort to walk or get out bed. People may just think they are getting old and it is not till other symptoms develop that you may think about PD. * Stiffness of muscles (rigidity) and muscles may feel tenser. Also, your arms do not tend to swing as much when you walk. * Shaking (tremor) is common, but does not always occur. It normally affects the fingers, thumbs, hands, and arms, but can affect other parts of the body. It is most noticeable when you are resting and may become worse when you are anxious or emotional. Itââ¬â¢s generally less obvious when you use your hand to do something such as picking up an object or writing. Symptoms will tend to get worse and worse and as the disease develops. Some other symptoms may develop due to problems with the way affected brain cells and nerves control the muscles. These include: * Fewer facial expressions such as smiling or frowning. Less blinking. * Difficulty with fine movements such as tying shoe laces or buttoning shirts. * Difficulty with writing (handwriting tends to become smaller), balance and posture and swallowing. * Speech may become slow and monotonous. * Tiredness aches and pains. As PD gets really bad, symptoms such as the following might develop, dependant on the individual: * Constipation- â⬠PD prevents the proper transmission of the neurological messages that tell the rectal sphincter muscles to openâ⬠7 * Hallucinations (seeing, hearing or smelling things that are not real) * Sweating- PD can affect the autonomic nervous system8 that controls the autonomic functions (functions done automatically by the brain and body without conscious thought) such as sweating, breathing etc. * Difficulties with sleeping * Weight loss- there is a generally decreased appetite associated with PD. This may largely be due to swallowing difficulties and other gastrointestinal disturbances8 * Pain * Depression Anxiety- anxiety disorders occur in up to 40% of patients with Parkinsonââ¬â¢s disease (PD)9. The article states â⬠Current evidence suggests that anxiety may not be a psychological reaction to the illness but rather may be linked to specific neurobiological processes accompanying PD.â⬠* Problems with controlling impulses (for example compulsive eating, shopping or gambling) Most people will only suffer form a few of these symptoms and which ones will get worse and the speed at which they get worse varies hugely from person to person. Some rare brain diseases can have very similar symptoms in which case a specialist brain scan can often be used to distinguish between them. The Treatments At the moment there is no cure for PD and most treatments simply have the job of relieving symptoms. 1. Drugs Intro: there are two main types of drug used in PD treatment. Firstly, drugs that target the neurotransmitter systems (e. You read "Parkinsons Disease" in category "Papers"g. dopamine) or secondly drugs that are designed to interfere with steps in the neurodegenerative processes (they may aim to sustain nerve cells or tackle the issue of free radicals). Drugs are cheap and effective, especially in relieving symptoms but show little potential as a full cure to the disease. Most also need to be taken daily for the remainder of a patients lifetime. Many drugs may have minor side affects. Some side affects have social impacts such as mood swings or may not allow the user to fly or travel to certain places. Dopaminergic Agents- use to activate the production or use of Dopamine. Levodopa- is an amino acid that is converted in the brain into dopamine. According to the WE MOVE website10 ââ¬ËLevodopa was introduced as a PD therapy in the 1960s, and remains the most effective therapy for motor symptomsââ¬â¢ although there are many drugs that do a similar job such as Rasagiline. It reduces the effect of and helps control the symptoms of PD. Like most amino acids levodopa is absorbed into the blood stream through the wall of the intestines. Amino acids require a ââ¬Ëtransporterââ¬â¢ to transfer them across the membrane of the intestines and into the blood stream. These transporters can only work at a certain rate and so diet is important. To much dietary protein can slow the transport of levodopa into the blood stream meaning the dose may be ineffective. Alternatively to avoid the competition with other amino acids, doses should be taken between meals. Levodopa has to cross from the blood stream into the brain using the same transport system again, making diet and timing doubly important. MAO-B Inhibitors- slow the breakdown of dopamine in the brain and aim to prevent or slow the death of neurons. ââ¬ËMAO is responsible for the mitochondrial metabolism of monoamine neurotransmitters, including dopamine and serotonin.ââ¬â¢11 Ethical implications Some of the many ethical issues revolve around the decision to move from testing on artificial tissue (often grown from stem cells, which may in the future replace animal testing altogether. Stem cells, however create there own ethical issues) to animals, and further on the line, of animal testing to trails on human patients. The graph below shows the stages involved in developing a new drug and is taken from the MSD website (21/3/10): (http://www.msd.com.hk/health_info/drug_education/e_ddp_introduction.html) Animal testing is very closely regulated in the UK however many, often false, accusations of animal abuse have lead to darkened perceptions of animal testing in the public eye. Animal abuse is definitely a reality but ââ¬Ëimproved transparency, accountability and regulationsââ¬â¢12 should reduce it happening and make sure those responsible are prosecuted. Unlike humans, animals are unable to consent to testing. It is forced upon them and often involves a certain amount of pain, stress, suffering and discomfort. Researchers will try to reduce this, possibly using anaesthetics although this can often interfere with the drug being tested so the animal may have to suffer the full amount of pain. Unfortunately, in PD, a number of animals are tested on normally starting with mice or rats before moving on to monkeys and finally human trails. Some people believe that animals like monkeys and most primates shouldnââ¬â¢t be experimented upon as they arenââ¬â¢t in the same plentiful supply that rats and mice are in, nor are they considered pests. However, for potentially dangerous drugs it is essential animals with a similar genetic make up (primates) are tested on to greatly reduce the risks in human clinical trails. Economics of drugs in PD As shown in figure 1.2 drug development requires a huge amount of research and testing and can take more than 10 years before a useable drug is created. This obviously requires a huge amount of investment and general drug development costs vary between 500 and 2,000 million dollars. R;D is often done by independent companies or government organizations. Most companies or organizations will link with universities to share information and facilities and hopefully quicken to process of discovering a new drug. ââ¬ËAfter approval, pharmaceutical companies have a short period of exclusivity before patents expire and other companies can market the same drugs as generics. This time is used to recoup the massive investment required to develop and launch a new drug. However, the companies must also continue to test their drugs and monitor the feedback from healthcare professionals in order to identify undiscovered side effects, risk factors and interactions.ââ¬â¢13 Drug companies are some of the most profitable industries in the world and although a large amount of money is needed in research and development (R;D) only 1 in 5 dollars made is then invested in further research. Many companies spent nearly twice as much money on advertising and marketing than R;D and demand is so much higher than it needs to be that companies can afford to boost prices to maximise profit. Luckily with PD this becomes less of a problem as people are unlikely take and therefore buy drugs that are meant for PD when they donââ¬â¢t actually need it. This is because the symptoms tend to be quite clear and drugs like levodopa are not readily available unless prescribed. Benefits to humans Drugs can have a massive impact on people suffering from PD and they aim to do a number of things: 1) Improve standards of living- by reducing the affects of PD and slowing the process of neurodegeneration it should allow the person suffering to do basic things (such as tying shoelaces, writing etc) more easily and for longer before they require full time medical care. This allows them to be more independent. 2) The use of drugs such as levodopa, in the long term, will reduce the affects of symptoms such as tiredness, aches and pains. Painkillers like amantadine will also be used for more short term relieve along side drugs like levodopa. This will simply make life less painful for a PD patient. 3) Drugs are the most well know and reliable of PD treatments. This reduces the risks of any unknowns or mistakes and far fewer mistakes will be made than in using other treatments. Risks to humans 1) Unfortunately Nausea and vomiting are common side effects of using levodopa that are due to the building up of dopamine in the bloodstream. The most serious and severe effect of this treatment is dyskinesias. ââ¬ËDyskinesias are uncontrolled movements, including writhing, twitching, and shaking. Dyskinesias result from the combination of long-term levodopa use and continued neurodegeneration. They typically begin to develop in milder forms after 3 to 5 years of treatment, but are more severe after 5 to 10 years of treatment.ââ¬â¢10 2) There is always risk of allergies when using drugs and for some unfortunate people drugs may do more damage than good. 3) Side affects of drugs vary from person to person and it is impossible to know beforehand how a certain drug will affect an individual. For some, side affects may be far worse than for others. 4) Dosages need to be got right and it is a common problem that people take to little and donââ¬â¢t get the full benefit of the drug or take to much and suffer more/worse side affects. A massive overdose will likely lead to death. Alternative Cures? 2. Gene therapy- is still in early research stages and it is likely to be a while before this technique is actually used on humans. Like stem cells it has exciting potential to provide a future cure and avoid the ethical issues associated with stem cells. How it works? Gene therapy aims to introduce new and functioning genetic material into cells that have abnormal genes that are causing proteins (in the case of PD, dopamine) not to be created or created faulty. The genetic material can normally be inserted into the cells using viruses. ââ¬ËSome types of virus, such as retroviruses, integrate their genetic material (including the new gene) into a chromosome in the human cell. Other viruses, such as adenoviruses, introduce their DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome.ââ¬â¢13There is still much development needed as scientists are still unable to target specific cells and there is the potential threat of virus mutation which may cause even further problems. There is also major worry about the potential for gene therapy to be used to improve basic human traits such as height, intelligence etc. People could simply choice characteristics and this in many peopleââ¬â¢s eyes could be used for the wrong reason. For example, this may be used to give some athletes a major advantage over others or possibly creating super humans. 3. Stem Cells I think stem cells have shown exciting potential and will hopefully provide a full time future cure for the disease. How they work? Stem cells are unspecialised cells that have the ability to develop into highly specialised cells like nerve cells. They can also self-renew, which means they are capable of replenishing themselves for long periods of time by dividing4. For Parkinsonââ¬â¢s disease it is hoped that large numbers of the brain cells that produce dopamine can be produced and inserted, through transplantation, into a patientââ¬â¢s brain. Therefore, nerve messages to all parts of the body will be normal again. However, stem cells not been successfully used to cure PD yet and there are many problems facing researchers. Therefore stem cells are relatively useless for PD at the moment but may be able to provide an easy and affective cure in the future. Problems with the types of Stem cells There are three main types of stem cells: 1. Adult stem cells can come from Skin, Bone marrow, Brain, Blood vessels, Liver and Skeletal muscle. However, adult stem cells are found in such small quantities it is difficult to identify and isolate them in viable numbers. Because adult stem cells arenââ¬â¢t as ââ¬Ëyoungââ¬â¢ as embryonic stem cells, they contain more DNA abnormalities acquired with age4. These can be caused by the environment, toxins or errors in DNA replication. Adult stem cells have limited potential because unlike embryonic stem cells they can not differentiate into any specialised cell in the body. 2. Cord blood cells are normally found in the umbilical cord and placenta after the cord is cut. One problem is the lack of cells obtained and these may not be enough relative to a patientââ¬â¢s size. Cord blood cells generally take longer to grow, therefore completion of therapy will take longer. It obviously requires a pregnant woman to donate the cells. 3. Embryonic stem cells are found in human embryos and have a seemingly unlimited potential to develop into any cell in the human body. However they are surrounded by a number of ethical issues. Many people and especially religious group condemn the use of embryonic stem cells as they believe it is destroying a life. They believe it is immoral to save a life at the expense of another. However new developments in stem cells research means that Totipotent* stem cells can now be collected without the loss of embryo life: Somatic cell nuclear transfer (SCNT) ââ¬â nucleus is removed from a somatic cell and is then implanted into a donor egg that has had its nucleus removed6. It divides just as normal before forming an embryo. Cells from the inner cell mass are extracted and cultured to provide embryonic stem cells but the technique destroys the embryo. Although the embryo is destroyed it is a created clone and so may not be considered the loss of new, individual life. Altered nuclear transfer (ANT), however, prevents an embryo from actually being created. The nucleus of the somatic cell is altered, or genetically reprogrammed, before being transferred into the egg. The alteration consequence is that the somatic cell DNA still produces stem cells but does not generate an embryo. Blastomere Extraction is performed on a two-day old embryo, following the division of the fertilized egg into eight blastomeres (cells). One blastomere is removed and can be triggered to divide and the resulting stem cells could still be used for research and disease treatment. The embryo, ââ¬Ënow with only seven blastomeres can still be implanted into the mother and assuming no defect has been found these embryos will still grow into healthy babiesââ¬â¢4. 1. Name of article: Parkinsonââ¬â¢s Disease Url: http://www.patient.co.uk/health/Parkinsonââ¬â¢s-Disease.htm Date accessed: 15/2/10 Evaluation: The article is certified as a reliable source of health and social care information. It certificate states- ââ¬ËThe authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest.ââ¬â¢ The article states that Parkinsonââ¬â¢s disease affects the part of the brain know as the substantia nigra. WE MOVE (Worldwide Education and Awareness for Movement Disorders- http://www.wemove.org/par/par_subn.html) states: ââ¬ËIn PD, cells of the SN (substantia nigra) degenerate, and therefore can no longer produce adequate dopamine.ââ¬â¢ This information is further backed up on the Parkinsonââ¬â¢s Disease Research Agenda that states ââ¬Ëcells that produce the neurotransmitter dopamine die in a small brain area called the substantia nigra.ââ¬â¢ As the information provided is backed by what I consider to be re liable resources I think that the information on the website is also therefore reliable, but should be checked with other sources before being used. 2. Name of article: Possible Causes of Parkinsonââ¬â¢s Disease (PD) Url: http://www.healthtree.com/articles/parkinsons-disease/causes.php Date accessed: 20/2/10 3. Name: Parkinsonââ¬â¢s Disease Research Agenda URL: http://www.ninds.nih.gov/about_ninds/plans/nihparkinsons_agenda.htm#Parkinson Date accessed: 20/2/10 Evaluation: Parkinsonââ¬â¢s disease Research Agenda is written by the National Institute of Neurological Disorders and Stroke (NINDS). It primary aim is to â⬠reduce the burden of neurological disease ââ¬â a burden borne by every age group, by every segment of society, by people all over the world.â⬠It is funded by the government so should provide no bias and the site aims to educate people about various neurological disorders including Parkinsonââ¬â¢s disease. It states ââ¬Å"mitochondrial dysfunction has numerous consequencesâ⬠¦ each of which may be important in Parkinsonââ¬â¢s disease.â⬠This is also backed by an article: http://www.nature.com/nrneurol/journal/v6/n2/full/nrneurol.2009.221.html that states â⬠dysfunctional energy metabolism might be a central element of the pathological process underlying the development of PD.â⬠The site was last updated on the 25th of July 2008. As the site is run and updated by the government with no other purpose but to inform I think it can be used a very reliable source of information. How to cite Parkinsons Disease, Papers
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